Can osteoarthritis in dogs be relieved with CBD?

Osteoarthritis occurs frequently in canines, usually associated with pain and restricted mobility. Recently, CBD for dogs (Cannabidiol) has been positioned as a promising natural option to mitigate the symptoms associated with osteoarthritis in dogs. It is crucial to stress the importance of consulting a veterinarian before giving CBD to pets, particularly in specific health situations.

What is osteoarthritis in dogs?

Osteoarthritis is defined as a degenerative condition affecting the joints, marked by deterioration of the articular cartilage. This process can trigger symptoms such as pain, swelling and reduced range of motion. Although this disease can manifest in canines of all breeds and ages, it tends to be more prevalent in older animals.

What is the function of cartilage?

Cartilage in dogs and other animals is a smooth layer that covers the bones in the joints, facilitating frictionless movement and acting as a shock absorber during activities such as jumping or running. Osteoarthritis in canines is characterized by the progressive deterioration of this cartilage, affecting its cushioning capacity and increasing wear and tear. This condition is divided into primary osteoarthritis, common in older animals due to natural wear and tear, and secondary osteoarthritis, which occurs after injuries or diseases, damaging the articular cartilage.

What are the symptoms of this disease in dogs?

To identify if a dog suffers from osteoarthritis, it is crucial to observe its behavior when moving, such as difficulties when climbing stairs or playing. A dog with joint pain will limit its movements, may limp and show changes in behavior, avoiding contact or even being aggressive. Advanced signs include locked joints, further restricting mobility. Detecting these symptoms early allows intervention before the dog’s condition seriously deteriorates.

Diagnosis of osteoarthritis in dogs

If you have noticed any of the above symptoms, regardless of your dog’s age, it is essential to consult a veterinarian. He or she will perform a detailed evaluation of your pet’s joints. To confirm the diagnosis, he will also rely on radiographs, which can validate or rule out the specialist’s previous hypotheses.

How does CBD act in a pet’s body?

CBD is one of the many components present in cannabis. It is distinguished by the fact that it has no psychoactive effects, i.e. it does not cause euphoric states in pets. On the contrary, CBD interacts with the body’s endocannabinoid system (ECS), an intricate network of cellular communication essential in the moderation of various functions such as sleep, appetite, pain perception and immune system activity.

Benefits of CBD in osteoarthritis in dogs

Today, both in France and the rest of Europe, a wide range of CBD-based products are available. For us humans, CBD oils, chewing gums, teas and vaporizing options are available. For our animal companions, CBD oil proves to be the most suitable option, as it can be administered directly under the tongue in those animals that tolerate it, such as dogs. CBD qualities include:

• Anti-inflammatory properties: CBD is recognized for its ability to effectively fight inflammation. Research has confirmed that CBD has comparable efficacy to traditional anti-inflammatory drugs, but without adverse side effects. Specific studies have validated the anti-inflammatory virtues of CBD (MECHA, et al. 2013, KOZELA et al. 2013, BUCCELLATO et al. 2011, RIBEIRO et al. 2012). A 2016 study revealed that CBD consumption increases the production of the anti-inflammatory cytokine IL-10 in participants (KOZELA et al.).
• Analgesic effect: Thanks to its anti-inflammatory action, CBD contributes to mitigate related pain. Numerous pet owners have reported positive results when using CBD to treat pain in animals. A study conducted by Philadelphia University in the United States suggests that CBD may be effective in managing certain types of pain.
• Improved sleep: Osteoarthritis can significantly interfere with a dog’s sleep, as the pressure exerted by the animal’s body when lying down can intensify pain in the affected areas. This causes the dog to wake up and seek a more comfortable position. It has been shown that CBD oil can prolong the duration and quality of sleep (Chagas et al. 2013).
• Anxiolytic and anti-stress effects: Constant pain, caused by every movement and even at rest, can have negative consequences on the mental health of dogs, inducing anxiety disorders. CBD oil, thanks to its calming properties, demonstrated both in animals (dogs, cats, etc.) and humans (Campos et al. 2012, Elbatsh et al. 2012), can alleviate pain symptoms, reducing anxiety and stress levels.

Conclusion

CBD is presented as a natural option to mitigate the symptoms associated with osteoarthritis in canines. There are testimonials from owners who have observed an increase in mobility and quality of life in their animals. However, it is crucial to be aware of the potential consequences and costs, and it is imperative to consult with a veterinarian before giving CBD to your animal companion.

Regarding legal considerations: While CBD is permitted in many regions of the world, there are still areas where its use is prohibited. It is essential to be informed about the regulations in force in your locality before opting for CBD for your pet.

Bibliography and Digital Sources

• Abrahamov, A., Abrahamov, A., Mechoulam, R. 1995. An efficient new cannabinoid antiemetic in pediatric oncology. Life Sci. 56: 2097-2102.

• Bonini, S.A., Premoli, M., Tambaro, S. et alt. 2018. Cannabis sativa: a comprehensive ethnopharmacological review of a medicinal plant with a long history. J. Ethnopharmacol. 227:300-315.

• Bradley, S., Young, S., Bakke, A.M. et alt. 2022. Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs. Front. Vet. Sci. 9: 122-130.

• Brioschi, F.A., Di Cesare, F., Gioeni, D., et alt. 2020. Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis. Animals (Basel) 10 (9): 1505-1510.

• Cluny, N.L., Naylor, R.J,. Whittle, B.A., Javid, F.A. 2008. The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus. Basic Clin. Pharmacol. Toxicol. 103:150-156.

• Della Rocca, G., Di Salvo, A. 2020. Hemp in Veterinary Medicine: From Feed to Drug. Front. Vet. Sci. 7: 387-392.

• Fallahi, S., Bobak, L., Opalinski, S. 2022. Hemp in animal diets Cannabidiol. Animals (Basel) 12 (19): 2541-2543.

• Gamble, L.J., Boesch, J.M., Frye, C.W., et alt. 2018. Pharmacokinetics, safety and clinical efficacy of cannabidiol treatment in osteoarthritic dogs. Front. Vet. Sci. 5: 165-170.

• García, G., Kube, S., Carrera-Justiz, S. et alt. 2022. Safety and efficacy of cannabidiol-cannabidiolic acid-rich hemp extract in the treatment of refractory epileptic seizures in dogs. Front. Vet Sci. 9: 140-145.

• Lima, T.M., Santiago, N.R., Alves E.C.R., et alt. 2022. Use of cannabis in the treatment of animals: a systematic review of randomized clinical trials. Anime. Health Res. Rev. 23 (1): 25-38.

• McGrath, S. 2017. Efficacy of Cannabidiol (CBD) for the Treatment of Canine Epilepsy. Grant of American Brittany Club.

• McGrath, S., Bartner, L.R., Rao, S. et alt. 2019. Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy. J. Am. Vet. Med. Assoc. 254 (11): 1301-1308.

• Mechoulam R. 2005. Plant cannabinoids: a neglected pharmacological treasure trove. Br J Pharmacol. 146: 913-915.

• Morrow, L., Belshaw, Z. 2022. Is cannabidiol an effective supplementary treatment for reducing paining dogs with osteoarthritis?. Vet. Rec. 191 (10): 420-421.

• United Nations. 1961. Single Convention on Narcotic Drugs. UN Publications. New York. 25 pp

• Parker, L.A., Rock, E.M., Limebeer, C. L. 2011. Regulation of nausea and vomiting by cannabinoids. Br. J. Pharmacol. 163 (7): 1411-1422.

• Perry, M.S. 2019. Don’t Fear the Reefer-Evidence Mounts for Plant-Based Cannabidiol as Treatment for Epilepsy. Epilepsy Curr. 19 (2): 93-95.

• Sánchez-Valverde, M.A. 2014. Pathology of the locomotor system. Editorial Diego Marín Librero Editor. Murcia. 429 pp.

• Sánchez-Valverde, M.A., Navarro Alberola, A., Murciano Pérez, J. 2015. Orthopedic and articular conditions of the forelimb. Editorial Diego Marín Librero Editor. Murcia. 367 pp.

• Sánchez-Valverde, M.A., Navarro Alberola, A., Murciano Pérez, J. 2015. Orthopedic and articular conditions of the hindlimb. Editorial Diego Marín Librero Editor. Murcia. 440 pp.

• Sánchez-Valverde, M.A., Murciano, J., Navarro, A., Paredes, J. 2016. Surgery of the spine. Editorial Diego Marín Librero Editor. Murcia. 516 pp.

• Sánchez-Valverde, M.A., Zilberchstein, J., Carrillo Sánchez, J.D. 2022. Osteoarthrosis: introduction, concept and arthrology in general. Canis and Felis 20: 6-13.

• Szaflarski, J.P., Bebin, E.M., Comi, A.M. et alt. 2018. CBD EAP Study Group. Epilepsia 59 (8):1540-1548.

• Van Sickle, M.D., Oland, L.D., HO, W., et alt. 2001. Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret. Gastroenterology. 121:767-774.

• Vaughn, D., Paulionis, L., Kulpa, J. 2021. Randomized, placebo-controlled, 28-day safety and pharmacokinetics evaluation of repeated oral cannabidiol administration in healthy dogs. Am. J. Vet. Res. 82 (5): 405-416.

• Wakshlag, J., Schwark, W., Deabold, K. et alt. 2020. Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract. Front. Vet Sci. 7: 505-508.

• Wang, T., Zakharov, A., Gomez, B., et alt. 2022. Serum cannabinoid 24h and 1week steady state pharmacokinetic assessment in cats using a CBD/CBDA rich hemp paste. Front. Vet. Sci. 9: 225-236.

• Yu, C.H.J., Vasantha Rupasinghe, H.P. 2021. Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation. Res. Vet. Sci. 140: 38-46.

• Zilberchstein, J., Sánchez-Valverde, M.A. 2014. Physiotherapy and rehabilitation in veterinary medicine. Editorial Diego Marín Librero Editor. Murcia. 347 pp.